National Capability Database | Capability Detail
Eileen Ingham
Biocompatibility/immunology of prosthetic wear particles and biomaterials
Capability Description
Leeds has a unique capability in developing testing methods to understand the biological consequences of exposure to biomaterials for tissue replacement in the musculoskeletal system. Examples of Leeds’ range of capability include: development of biocompatibility assays for a range of biomaterials; understanding how wear debris particles of a medical device interact with macrophages; development of assays to evaluate how biomaterials interact with the specific immune system.
Case Study
Professor Ingham has recently extended studies of wear particle interactions with cells to spinal tissues, in light of the advent of total disc replacements. Leeds has an ongoing collaboration with Tom Brown from the University of Iowa, USA, funded by NIH (USA) on the isolation and characterisation of third body particles generated in hip replacement surgery.
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